Tuesday, November 11, 2008

Chronic pain - the oxygen connection

Oxygen, or lack of oxygen is involved in chronic pain pathways. Substance p is one of many neurotransmitters involved in clinical pain syndromes such as Complex Regional Pain Syndrome. Neurotransmitters transmit information across synapses. When released neurotransmitters either help or hinder electrical impulses along nerve fibers.

Substance p's relationship with oxygen deficit is well known. Oxygen deficit triggers the release of substance p. Experiments have shown that decreasing tissue oxygen concentrations increases release of substance p. The amount of substance p is relative to the level of hypoxia or put simply, the lower the amount of oxygen, the higher the amount of substance p.

It is already known that tissue hypoxia and an increase in skin lactate levels occur in Complex Regional Pain Syndrome. Oxygen free radical scavengers such as vitamin C reduce the pain of CRPS and bring about local oxygen homeostasis, inhibiting the release of substance p. Topical capsaicin (made from chillis) cream inhibits the release of substance p by increasing oxygen delivery. This, in essence, is merely a simplified explanation. Google "oxygen view of pain Majid Ali" for a more detailed explanation.

Dr Majid Ali recommends what he calls limbic breathing which he describes as a "vigorous type of breathing with a long out breath". My physiotherapist and my intergrative medicine doctor also recommend a the type of breathing where the out breath is longer or twice as long as the in breath. This type of breathing, I believe, activates the parasympathetic nervous system bringing about a sense of calm and thus helping us to better
cope with pain. Now I also realize that this style of breathing has the added benefit of encouraging increased oxygen intake.

To read more about Dr Majib and "The Oxygen View of Pain" click on this blog's title link.

Recently I've come to realize the benefit of alternate nostril breathing. Here are links to my recent post on this and a video demonstration.



Those of you with an interest in Hyperbaric Oxygen as a treatment for CRPS/RSD might be interested in this link to research articles.

For chronic pain sufferers it's important to remember to breathe.

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