Cutaneous tactile allodynia (painful hypersensitivity to mechanical stimulation of the skin) associated with microvascular dysfunction in muscleLaferriere, Millechamps, Xanthos, Xiao, Siau, de Mos, Sachot, Ragavendran, Huygen, bennett, Coderre. Click on the post title link for cantact information.
Molecular Pain 2008, 4:49doi:10.1186/1744-8069-4-49
|Published:||28 October 2008|
"Cutaneous tactile allodynia, or painful hypersensitivity to mechanical stimulation of the skin, is typically associated with neuropathic pain, although also present in chronic pain patients who do not have evidence of nerve injury. We examine whether deep tissue microvascular dysfunction, a feature common in chronic non-neuropathic pain, contributes to allodynia.
Our results demonstrate how microvascular dysfunction and ischemia in muscle can play a critical role in the development of cutaneous allodynia, and encourage the study of how these mechanisms contribute to chronic pain. We anticipate that focus on the pain mechanisms associated with microvascular dysfunction in muscle will provide new effective treatments for chronic pain patients with cutaneous tactile allodynia."
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