Monday, April 13, 2009

Importance of knowing pedisposing factors for development of CRPS.

My last post mentioned a new finding of a possible risk factor for developing CRPS. Not enough is known about predisposition to conditions such as complex regional pain syndrome. CRPS patients are left with chronic pain, vasodysregulation, and other symptoms. The predisposing factors are unknown. Genetic factors undoubtedly contribute, but have not yet been identified.

Researchers at Massachusetts General Hospital ( MGH ) have found the first evidence of a physical abnormality underlying CRPS. They reported four CRPS patients also diagnosed with the classical or hypermobility forms of Ehlers Danlos syndrome (EDS), inherited disorders of connective tissue. They hypothesized that "EDS might contribute to the development of CRPS.

The London Journal of Rheumatology September 2006, published an article about Japanese research "Headache may be a risk factor for complex regional pain syndrome".

They investigated whether or not headache and family history of headache were risk factors for CRPS. Their results suggested that headache and first-degree family history were risk factors but suggested further studies with larger numbers be carried out.

It seems that pilot studies are undertaken with promising results but little follow up is undertaken. It is my thought that there appears to be a hit or miss approach to research and not enough of which is publicly funded. An example of this is that Netherlands and UK research has found that taking 500mg of vitamin C after a colles wrist fracture can prevent development of complex regional pain syndrome. (This has now been updated to 1000mg in further studies.) It seems to me that if the underlying thing addressed by this study was inflammation and inflammation is an issue in general with CRPS that a broader study could possibly find eg, that taking vitamin C post surgery in general could prevent the development of CRPS.

1 comment:

Barbara K. said...

This is very important data. thanks for finding and reporting it.

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