The Lancet in December 1999 reported that doctors at Leyenburg Hospital, The Hague, The Netherlands in a prospective, double-blind study showed that vitamin C was associated with a lower risk of RSD after wrist fractures. They hypothesized that this beneficial effect of prophylaxis would be useful in other forms of trauma.Researchers at Centre Hospitalier, Rue Marcellin Berthelot, 02 000 Laon, France found that the incidence of reflex sympathetic dystrophy was five time times lower in a group give vitamin C orally for 45 days from the start of the fracture. They considered that this supported previous observations and lent credibility to the value of vitamin C administration as a prophylactic measure to prevent the occurrence of reflex sympathetic dystrophy in patients who undergo surgical treatment of a displaced fracture of the distal radius.
In July 2007 the Journal of Bone & Joint Surgery reported that Drs Zollinger, Tuinebreijer, Breederveld and Kreis, Department of Surgery, Red Cross Hospital, Beverwijk, The Netherlands had conducted a randomized, controlled, multicenter dose-response study into whether vitamin C can prevent the development of Complex Regional Pain Syndrome in patients with wrist fractures.
The study concluded that Vitamin C reduces the prevalence of complex regional pain syndrome after wrist fractures. A daily dose of 500 mg for fifty days was recommended recommended.