Oxygen, or lack of oxygen is involved in chronic pain pathways. Substance p is one of many neurotransmitters involved in clinical pain syndromes such as Complex Regional Pain Syndrome. Neurotransmitters transmit information across synapses. When released neurotransmitters either help or hinder electrical impulses along nerve fibers.
Substance p's relationship with oxygen deficit is well known. Oxygen deficit triggers the release of substance p. Experiments have shown that decreasing tissue oxygen concentrations increases release of substance p. The amount of substance p is relative to the level of hypoxia or put simply, the lower the amount of oxygen, the higher the amount of substance p.
It is already known that tissue hypoxia and an increase in skin lactate levels occur in Complex Regional Pain Syndrome. Oxygen free radical scavengers such as vitamin C reduce the pain of CRPS and bring about local oxygen homeostasis, inhibiting the release of substance p. Topical capsaicin (made from chillis) cream inhibits the release of substance p by increasing oxygen delivery. I use capsaicin cream, however some research has shown that there is no difference between placebo and capsaicin cream. Both reduce pain. (I'll write about placebo in another post.) This, in essence, is merely a simplified explanation. Majid Ali's "Oxygen view of pain" explains more.
Dr Majid Ali recommends what he calls limbic breathing which he describes as a "vigorous type of breathing with a long out breath". My physiotherapist and my integrative medicine doctor also recommend a the type of breathing where the out breath is longer or twice as long as the in breath. This type of breathing, I believe, activates the parasympathetic nervous system bringing about a sense of calm and thus helping us to better cope with pain. Now I also realize that this style of breathing has the added benefit of encouraging increased oxygen intake.
For chronic pain sufferers it's important to remember to breathe.
crps/rsd related articles
- Nursing Patients with CRPS/RSD
- Vitamin c and CRPS 2010
- Cleveland Clinic link - twin research
- Complex Regionaal Pain Syndrome and identical twins.
- Familial occurance of CRPS.
- Headache a risk factor for CRPS.
- Ehlers Danlos Syndrome and CRPS
- Brain change in chronic CRPS -Neuron
- Vitamin c as preventative for CRPS - Netherlands study 2007
- Vitamin C and CRPS study ARC Bristol
- BestBETs Best Evidence Topics - Hydrotherapy for Comples Regional Pain Syndrome (CRPS) of the foot and ankle
- Neurotopian - Matthias Weinberger's fantastic blog.
- hope-4crpsrsd - a Christian support group
- podcast - Australian Native Fruits bear sweet antioxidants.
- Explain Pain - David Butler's blog
- CRPS/RSD and Dentistry
- HTCwP - brain control of movement is altered in CRPS - study
- HTCwP - Self Compassion or Self Esteem
- Neuromatrix Training Blog
- Neurodynamics - Physical and Neural Health Blog
- Explain Pain Blog
- JB & JS report - Can Vitamin C Prevent Complex Regional Pain Syndrome in Patients with Wrist Fractures?
- Matthais Weinberger's interview on "how to Cope with Pain" website.
- How to Cope with Pain - Ketamine Coma treatment for CRPS/RSD
- RSDHope - DVD set of three
- North Western University Feinburg School of Medicine "Old Memory Traces May trigger chronic pain."
- HOw to Cope with pain How Pain Affects Families -Tony's story.
- Prevention.com article -"Natural-Born Pain Killers"
- Brain control altered in movement with CRPS -How to Cope With Pain
- How to Cope With Pain - Asking for help.
- Hooshmand and Physical Therapy Part I
- Hooshmand and Physical Therapy Part II
- How to Cope with Pain on Recognize - Here's a way to get ready to move - with less pain.
- American Pain Foundation Booklet: Treatment Options - A Guide for People Living in Pain
- Preventing CRPS after surgery - International Research Foundation for RSD/CRPS
- How to Cope with Pain - great questions about Graded motor movements
- How to Cope with Pain - Recognize podcast
- How to Cope with Pain - Graded motor imagary
- How to Cope with Pain - Think & move & your pain will improve.
- How to Cope with Pain - CRPS - Can mirrors help?
- RSD Canada Online Survey Questionnaire
- For Grace web site
- For Grace Utube site
- How to Cope With Pain - Can mirrors help?
- Noi Group Australia
- Support groups help you cope with pain - HTCWP interview by National Pain Foundation
- How to Cope with Pain Mindfulness video from Utube.
- "How to Cope with Pain's" hilarious video.
- Jason's RSDS/CRPS News & Information blog
- BBC UK News - Vitamin C /crps study - "Mystery pain left me in a wheelchair"
- Dr Moseley's interview on How to Cope with Pain site.
- Virtual Reality as a Rehabilitative Technology for Phantom Limb Experience.
- UK mirror box therapy site.
- Ramachandran's mirror box video
- My interview on "How to Cope with Pain" website.
- Napp Pharmaceuticals donate mirror boxes - WebWire article
- How to Cope with Pain: A guide to coping with pain.
- Hooshmand and Physical Therapy Part II
Gadget by The Blog Doctor.http://www.blogdoctor.me/2009/01/random-rotating-post-gadget-with.html#ixzz0KYNw8qB2&D