Thursday, December 01, 2011

Dutch researchers' studies supported the theory that oxygen derived free radicals are possibly the mediators of mechanisms leading to some of the neurological symptoms of CRPS.

First suggested by Sudeck in 1942, Dutch researchers' studies supported the theory that oxygen derived free radicals are possibly the mediators of mechanisms leading to some of the neurological symptoms of CRPS. They found

  • high oxygen supply with tissue hypoxia in CRPS extremities;
  • a diminished oxygen availability to the skeletal muscle tissue affected by chronic CRPS;
  • and several deficiencies in the skeletal muscles of CRPS sufferers
Studies in Holland have centered around free radical scavengers as treatment for CRPS. There are many ongoing studies with DMSO, NAC in Holland.

This is supported by research in Israel serum and salivary oxidative analysis in complex regional pain syndrome.

Free radicals are atoms or groups of atoms with an odd number of electrons and can be formed when oxygen interacts with certain molecules. Once formed these highly reactive radicals can start a chain reaction. Their chief danger comes from the damage they can do when they react with important cellular components such as DNA, or the cell membrane. To prevent free radical damage the body has a defense system of antioxidants.
Antioxidants are molecules which can safely interact with free radicals and terminate the chain reaction before vital molecules are damaged. Although there are several enzyme systems within the body that scavenge free radicals, the principle micronutrient (vitamin) antioxidants are vitamin E, beta-carotene, and vitamin C. Additionally, selenium, a trace metal that is required for proper function of one of the body's antioxidant enzyme systems, is sometimes included in this category. The body cannot manufacture these micronutrients so they must be supplied in the diet.
Vitamin E : nuts, seeds, vegetable and fish oils, whole grains (esp. wheat germ), fortified cereals, and apricots.
Vitamin C : Ascorbic acid is a water soluble vitamin present in citrus fruits and juices, green peppers, cabbage, spinach, broccoli, kale, cantaloupe, kiwi, and strawberries.
Beta-carotene is a precursor to vitamin A (retinol) and is present in liver, egg yolk, milk, butter, spinach, carrots, squash, broccoli, yams, tomato, cantaloupe, peaches, and grains. (NOTE: Vitamin A has no antioxidant properties and can be quite toxic when taken in excess.)
Research now shows that we can substantially affect the level of anti-oxidants in our bodies by eating fresh fruits and vegetables.

Google "antioxidants for crps" to learn more.

Remember the research about vitamin c's ability to prevent CRPS after some orthopedic surgery!


Jane in Pain said...

I am aussie too, but I live in the Netherlands. I've heard that they advise all patients showing early symptoms of CRPS to take extra vitamin C, especially after wrist fractures (a common occurance from falling from a bike!). I take it too, well here and there ;)

jeisea said...

The recommendation is to take 500mg (later research says 1000mg) of vitamin c (you can get it from food) from the time of injury for 50 days or until pain goes. Vitamin c reduces inflammation which is thought to have something to do with developing CRPS. It is taken to try to prevent the development of CRPS. I had an email from someone doing research in the Netherlands in answer to my question, "if vitamin c can prevent crps, can it also be used to treat the condition." The reply indicated that although it is possible the Netherlands is a small country and so is limited in it's catchment of patients for such research.

Jane in Pain said...

yes, that can be the reaction over here! I have to be very proactive with my treatment. My doctor here does his best, but I get the same head-tilting "sorry, we can't do much..." response. The population is just under 17mil, so it's not that small! And it is becoming more common, I know more people who are getting CRPS after accidents. Thanks for the guidelines, I'll give it a (better) try!! Have you found it makes a difference?

Custom Search
Gadget by The Blog Doctor.